Our research
The GCI
Research Mission
Research at the GCI addresses unmet clinical needs in cancer by discovering how tumours initiate and progress, identifying their weaknesses, and developing strategies to target them. We are a hub of broad, multidisciplinary networks linking the laboratory and the clinic, working together to use the knowledge gained from fundamental investigation to improve outcomes for cancer patients.
Discover the mechanisms
that drive cancer
GCI research integrates advanced technology with computational biology and AI, unique samples and data from our clinical partners, and state-of-the-art cancer modelling to discover the genomic changes, signaling pathways, microenvironmental factors and environmental influences (such as diet and lifestyle) underlying cancer initiation and progression. Our collaborative, interdisciplinary approach reveals how these cancer drivers work and interact at the molecular, cellular, and whole-organism levels, leading to new therapeutic targets and breakthroughs for hard-to-treat cancers.
Create new ways to
understand cancer
Where existing technology cannot answer the questions or provide the insight we need, GCI investigators develop new methods and next generation technologies to pinpoint cancer’s driving factors and expose its therapeutic vulnerabilities. We are pioneers of many techniques now used around the world to understand cancer at a fundamental level, designers of complex models that capture all aspects of cancer biology and physiology, and developers of “big data” technologies, AI and computational medicine approaches to unravel the molecular and cellular complexities of cancer.
Advance precision cancer medicine
and lead biomarker discovery
Cancer encompasses a wide spectrum of diseases with distinct genomic and biological characteristics. Precision medicine aims to predict whether cancer subtypes will respond to or resist therapies and match patients with the best treatment. Based on our fundamental knowledge, and empowered by our network of clinical partnerships, we use “-omics” technologies, cutting-edge imaging, metabolic analysis, and AI to uncover measurable indicators, or biomarkers, associated with progression and drug response or resistance in specific cancers. This leads to new and better ways to predict risks and outcomes, and to match patients with the best treatments. Our ability to model distinct cancer subtypes in the lab, including rare and hard-to-treat forms of the disease, validates key clinical observations and reveals the mechanisms behind them. It also allows us to advance precision cancer medicine by discovering and testing new, more effective therapies for hard-to-treat cancers in the most accurate ways possible.
GCI Research Areas
We work primarily within six Research Areas, focusing on key challenges in cancer
research and leveraging the unique and diverse strengths of our community.
Cancer
Metabolism
Metabolism drives cancer progression, metastasis and drug resistance. The GCI is pioneering research into cancer metabolism to develop new treatment strategies.
Tumour
Microenvironment
Research at the GCI advances our fundamental understanding of the tumour microenvironment to develop new precision medicine strategies for cancer.
Cancer Genome
Biology
The GCI develops fundamental knowledge of how the genomic drivers of cancer operate and how the cancer genome is modified and functionalized to promote tumour progression.
RNA Biology
and Therapeutics
GCI researchers lead the way in RNA biology research, discovering fundamental mechanisms and innovative RNA-based therapies for cancer.
Early-stage
Cancers
To capitalize on early cancer detection, we discover biomarkers and new targets that enable precision medicine strategies to improve outcomes by eliminating early-stage cancers before they progress.
High-fatality
Cancers
The GCI aims to develop new treatments for cancers with a poor prognosis by discovering mechanisms of metastasis and drug resistance and finding therapeutic targets for rare and understudied cancers.
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