Rosalind and Morris Goodman Cancer Institute (GCI) alumnus Maxwell Shafer shares the diverse scientific path that led him to become an Assistant Professor at the University of Toronto. From frogs to zebrafish here and abroad, Prof. Shafer’s career exemplifies the importance of fundamental scientific discoveries while exploiting the versatility of model organisms.
Early Ambitions and Research Journey at GCI
Max Shafer spent many hours watching nature documentaries with his parents as a child. The vibrant footage and captivating narration sparked his interest in life sciences which he held onto until being introduced to the world of research during his undergraduate studies. During this time, he learned much about embryology and stem cells in model organisms, particularly in frogs, which further inspired him to pursue graduate studies at the GCI under the supervision and mentorship of Prof. Maxime Bouchard. Here, Max focused on understanding the role of the transcription factor Gata3 in prostate stem cell differentiation.
From Cancer Research to Evolutionary Genomics
After completing his PhD at McGill University, Max began his postdoctoral work with Prof. Alex Schier, initially at Harvard University and now relocated to the University of Basel. This transition marked a shift towards exploring single-cell genomics in neuroscience and evolutionary biology. In July 2023, Max took on the role of Assistant Professor at the University of Toronto in the Department of Cell & Systems Biology. Now, Prof. Shafer studies the evolution and genomics of sleep across species (when, where, and how different animals sleep): “We also aim to look at our results through the lens of evolutionary medicine, with the goal to better understand the what, why, and how of human sleep.”
Impact of GCI Experience on Career Development
Prof. Shafer attributes much of his professional growth to his time at GCI: “I think the biggest impact was the exceptional level of science that surrounded me at the GCI, and the many excellent mentors and colleagues that helped me while I was there.” Despite moving away from cancer research, the foundational training in genetics and genomics at GCI remains pivotal in his current research endeavors. The invaluable skills he acquired during his training at GCI continue to shape his approach to scientific inquiry and leadership. The exposure to cutting-edge research methodologies and the culture of academic excellence have been instrumental in his career trajectory.
Advice for Aspiring Scientists
Prof. Shafer advises aspiring researchers to maintain a forward-thinking mindset and strategic planning in career transitions: “Looking back, I think the most useful thing I did was to always be thinking ahead. I began thinking about and searching for postdoc positions 2-3 years before I defended, and throughout my postdoc, I considered how my research decisions (what to study and how) impacted my ability to apply for academic positions.” He emphasizes the importance of clarity in career goals while remaining adaptable to evolving research interests and opportunities.
Recognition and Memorable Moments
During his time at GCI, Prof. Shafer received several prestigious awards and fellowships, including support from McGill University Faculty of Medicine, Prostate Cancer Canada and the Karassik Family Foundation. Reflecting on memorable moments, Prof. Shafer fondly recalls meeting Prof. Ahilya Sawh during their PhD studies at the GCI. “We subsequently both pursued postdoctoral studies after we graduated from McGill, with both of us spending time at Harvard before moving to Switzerland.” Currently, Prof. Ahilya Sawh is also a Professor at the University of Toronto. “This would all be quite a coincidence, except for the fact that we’ve been married for nearly 8 years,” shares Prof. Shafer warmly.
Prof. Max Shafer's journey from GCI to his current role exemplifies the impact of foundational research training on shaping future scientific leaders. Thank you, Max, for sharing your story with us.
Shafer is actively recruiting prospective students to continue exploring the mysteries of sleep through an evolutionary lens. To learn more about Prof. Shafer’s research or interest in joining his research group, please see PubMed, Google Scholar, Lab website.
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