1. Understanding the molecular mechanisms that underpin pro-inflammatory hematopoiesis and how this can be targeted to reduce systemic inflammation and cancer progression
2. Unravelling the impact of estrogen signaling on hematopoiesis and how estrogen deficiency (menopause) leads to chronic inflammation

Metastasis is the leading cause of cancer-related deaths, underscoring the urgent need for innovative treatments. Chronic systemic inflammation plays a critical role in driving metastasis, with signals from mammary tumors inducing functional changes in inflammatory cells. These changes occur at multiple levels: during their development in the bone marrow, within tissues, and in the formation of (pre-)metastatic niches. Despite this, therapies targeting pro-metastatic inflammatory cells remain limited.

Our research focuses on unraveling the mechanisms by which chronic systemic inflammation evolves in breast and ovarian cancer and identifying new therapeutic targets.